Session 1 Chair: Backofen 14:40 *** Mercator fellow lecture *** Eugene Koonin Guns for hire: evolutionary entanglement between CRISPR and other host defense systems and mobile genetic elements 15:10 David Burstein Discovery of CRISPR–Cas systems from uncultivated microbe 15:40 Konstantin Severinov Decoding the mechanism of CRISPR interference by RNA-guided RNAtargeting Cas13a effector
16:10 Coffee & Tea Break
Session 2 Chair: Hess 16:30 Julia Wörtz (Marchfelder lab) Functions beyond defence: Cas1 and DNA repair in Haloarchaea 17:00 Xiaohan Guo (Randau lab) Structural and functional insights into Type IV CRISPR-Cas systems 17:30 Christopher-Nils Mais (Bange lab) Towards a complete mechanistical understanding of the Type I-Fv CRISPR system
18:00 – 19:00 Dinner
19:00 – 22:00 Beer & Posters
Tuesday, March 24
Session 3 Chair: White 9:00 Ben F. Luisi Bacterial ribonucleases and chaperones in riboregulation 9:30 Wolfgang Hess CRISPR-Cas Systems in Cyanobacteria: Interactions with the Cellular Regulatory Machinery 10:00 Heike Ziegler CRISPR-Whisper Report 10:30 Rolf Backofen CRISPRcasIdentifier: Machine learning for accurate identification and classification of CRISPR-Cas systems
11:00 Coffee & Tea Break
Session 4 Chair: Severinov 11:30 Bartosz Turkowyd (Endesfelder lab) Exploring CRISPR-Cas systems in vivo 12:00 Jochem Vink (Brouns lab) The influence of target search dynamics on natural occurring phage-host interactions 12:30 Ralf Seidel Target recognition by Type I CRISPR-Cas systems
13:00 Lunch & Posters
Session 5 Chair: Koonin 14:15 Uri Gophna CRISPR-Cas systems, proviruses and the pangenomes of bacteria and archaea 14:45 Tobias Maier (Voß lab) The diversity of CRISPR systems in metagenomes 15:15 Tatiana Dimitriu (Westra lab) Antibiotic stresses modify the evolution of phage resistance in Pseudomonas aeruginosa 15:45 Franz Baumdicker The cost and benefit of distributed CRISPR systems
16:15 Coffee & Tea Break
Session 6 Chair: Gophna 16:45 Elisabeth Wörle (Grohmann lab) The bridge helix governs the conformational cycle and cleavage accuracy of Cas12a 17:15 Sabine Schneider Structure-function relationship of Cas13a from Rhodobacter capsulatus 17:45 Henning Urlaub How to decipher protein interactions within cells by mass spectrometry
18:15 – 19:15 Dinner
19:15 – 22:00 Beer & Posters
Wednesday, March 25
Session 7 Chair: Randau 9:00 Malcolm White Virus:host conflict involving cyclic nucleotide signalling 9:30 Robert Fagerlund (Fineran lab) Internal translation of CRISPR-Cas large subunit genes provides small subunits for effector complex formation 10:00 Chase Beisel CRISPR-Cas systems block formation of “extraneous” CRISPR RNAs through distinct mechanisms 10:30 Philipp Münch (McHardy lab) Natural CRISPR systems and targets in the human microbiome
11:00 Coffee & Tea Break
Session 8 Chair: Beisel 11:30 Christoph Schoen Deciphering the role of the CRISPR-Cas system in Neisseria meningitidis in host cell adhesion 12:00 Sahil Sharma (Cynthia Sharma lab) CRISPR-Cas9 mediated endogenous RNA targeting in the foodbornepathogen Campylobacter jejuni 12:30 Sebastiaan Meijsing (Charpentier lab) Using genome engineering to make or break transcription factor binding sites
CRISPR whisper 