Progamm Meeting des SPP2141 in Berlin

Monday, March 23
14:30 Welcome
Session 1 Chair: Backofen
14:40 *** Mercator fellow lecture ***
Eugene Koonin
Guns for hire: evolutionary entanglement between CRISPR and other host
defense systems and mobile genetic elements
15:10 David Burstein
Discovery of CRISPR–Cas systems from uncultivated microbe
15:40 Konstantin Severinov
Decoding the mechanism of CRISPR interference by RNA-guided RNAtargeting
Cas13a effector
16:10 Coffee & Tea Break
Session 2 Chair: Hess
16:30 Julia Wörtz (Marchfelder lab)
Functions beyond defence: Cas1 and DNA repair in Haloarchaea
17:00 Xiaohan Guo (Randau lab)
Structural and functional insights into Type IV CRISPR-Cas systems
17:30 Christopher-Nils Mais (Bange lab)
Towards a complete mechanistical understanding of the Type I-Fv
CRISPR system
18:00 – 19:00 Dinner
19:00 – 22:00 Beer & Posters
Tuesday, March 24
Session 3 Chair: White
9:00 Ben F. Luisi
Bacterial ribonucleases and chaperones in riboregulation
9:30 Wolfgang Hess
CRISPR-Cas Systems in Cyanobacteria: Interactions with the Cellular
Regulatory Machinery
10:00 Heike Ziegler
CRISPR-Whisper Report
10:30 Rolf Backofen
CRISPRcasIdentifier: Machine learning for accurate identification and
classification of CRISPR-Cas systems
11:00 Coffee & Tea Break
Session 4 Chair: Severinov
11:30 Bartosz Turkowyd (Endesfelder lab)
Exploring CRISPR-Cas systems in vivo
12:00 Jochem Vink (Brouns lab)
The influence of target search dynamics on natural occurring phage-host
12:30 Ralf Seidel
Target recognition by Type I CRISPR-Cas systems
13:00 Lunch & Posters
Session 5 Chair: Koonin
14:15 Uri Gophna
CRISPR-Cas systems, proviruses and the pangenomes of bacteria and
14:45 Tobias Maier (Voß lab)
The diversity of CRISPR systems in metagenomes
15:15 Tatiana Dimitriu (Westra lab)
Antibiotic stresses modify the evolution of phage resistance
in Pseudomonas aeruginosa
15:45 Franz Baumdicker
The cost and benefit of distributed CRISPR systems
16:15 Coffee & Tea Break
Session 6 Chair: Gophna
16:45 Elisabeth Wörle (Grohmann lab)
The bridge helix governs the conformational cycle and cleavage accuracy of
17:15 Sabine Schneider
Structure-function relationship of Cas13a from Rhodobacter capsulatus
17:45 Henning Urlaub
How to decipher protein interactions within cells by mass spectrometry
18:15 – 19:15 Dinner
19:15 – 22:00 Beer & Posters
Wednesday, March 25
Session 7 Chair: Randau
9:00 Malcolm White
Virus:host conflict involving cyclic nucleotide signalling
9:30 Robert Fagerlund (Fineran lab)
Internal translation of CRISPR-Cas large subunit genes provides small
subunits for effector complex formation
10:00 Chase Beisel
CRISPR-Cas systems block formation of “extraneous” CRISPR RNAs
through distinct mechanisms
10:30 Philipp Münch (McHardy lab)
Natural CRISPR systems and targets in the human microbiome
11:00 Coffee & Tea Break
Session 8 Chair: Beisel
11:30 Christoph Schoen
Deciphering the role of the CRISPR-Cas system in Neisseria meningitidis
in host cell adhesion
12:00 Sahil Sharma (Cynthia Sharma lab)
CRISPR-Cas9 mediated endogenous RNA targeting in the foodbornepathogen
Campylobacter jejuni
12:30 Sebastiaan Meijsing (Charpentier lab)
Using genome engineering to make or break transcription factor binding
13:00 Departure